Faculty of Chemical Engineering and Technology, Department of Organic Chemistry

PDF Export

Main research field

Organic chemistry, Medicinal chemistry, Photochemistry

Specific research areas

synthetic organic chemistry, synthetic photochemistry, spectroscopic characterization by means of NMR, IR, UV, GC/MS and HPLC/MS spectroscopy, spectroscopy studies by means of UV and fluorescence spec

Techniques/methods

organic syntheis, photochemical synthesis, micowave assisted organic synthesis, chromatographic separation and isolation, NMR spectroscopy, UV visible spectroscopy, fluorimetric spectroscopy, HPLC/MS spectroscopy, GC/MS spectroscopy, infrared spectroscopy

Equipment

GC/MS, HPLC-MS/MS, microwave oven for organic synthesis, UV visible spectrophotometer, fluorimeter, photochemical reactor

Technology keywords

  • Organic Substances
  • Pharmaceutics
  • Special chemicals, intermediates
  • Organic Chemistry
  • Separation Technologies

Services offered

  • Teaching and Training

Market sectors

  • Specialty Chemicals
  • Industrial Engineering
  • Food Producers
  • Health Care Equipment & Services
  • Pharmaceuticals & Biotechnology
  • Gas, Water & Multiutilities

Short summary (English)

Our research group has a broad expertise in the field of organic synthetic chemistry and design of novel organic heteroaromatic molecules for biological and photophysical application. The research group’s main focus is in organic synthesis and potential application of novel classes of organic compounds as it follows: a) benzimidazole, benzothiazole, benzimidazo-quinoline, benzo[b]thieno-quinolone, furane, thiophene, pyridine and isoindoline derivatives, triaza-fluorenes, naphthofuranes, naphthothiophenes, amidines, Schiff bases and heteroaromatic amides as potential chemotherapeutics and fluorescent DNA/RNA probes and spectroscopic binding studies of biologically active compounds with biomacromolecules DNA/RNA; b) 1,2,4-triazole, 1,3-imidazole, aza-pyrimidine, fluorinated deaza-purine and cyanuric acid derivatives of L-ascorbic acid and 1H-10-oxa-1,4-diaza-dibenzo[a,d]heptalene derivatives as putative agents against human maligmant tumors and pathogene viruses; c) purines and pyrimidines bearing saturated, unsaturated and 1,2,3-triazole substituents and byciclic oxazolo-, thieno-, furo-, imidazopyrimidines as potential cytostatic and antiviral agents and potential tracers for monitoring of maligmant tumors by positron emission tomography (PET); d) conjugated aromatic heterocycles, photochemical and photophysical properties, reaction mechanisms of electrocyclization and intra/intermolecular cycloadditions, synthesis of heteropolycycles as synthons for bioactive compounds, porphyrine ligands for photocatalysis and photodegradation of antibiotics. Besides standard organic synthesis methods, our research group possesses specific expertise in modern techniques such as 'click' chemistry-based approach, palladium catalyzed coupling reactions, photochemical reactions, photophysical study, microwave assisted organic synthesis, retrosynthetic approach in the synthesis of designed molecules and structural characterization of organic compounds by means of 1H-, 13C-, 19F-NMR, 2D NMR, IR, UV, CD, fluorescence and mass spectrometry

Short summary (Croatian)

Naša istraživačka grupa ima značajnu stručnost na području organske sintetske kemije i dizajniranja novih, organskih, heteroaromatskih spojeva za primjenu u biologiji i fotofizici. Glavni cilj istraživačke grupe je sinteza i moguća primjena novih skupina organskih spojeva kako slijedi: a) derivata benzimidazola, benzotiazola, benzimidazo-kinolina, benzo[b]tieno-kinolona, furana, tiofena, piridina i izoindolina, triaza-fluorena, naftofurana, naftotiofena, amidina, Schiffovih baza te heteroaromatskih amida kao potencijalnih kemoterapeutika i fluorescentnih proba za obilježavanje DNA/RNA kao i spektroskopska karakterizacija interakcije biološki aktivnih spojeva s biomakromolekulama DNA/RNA; b) 1,2,4-triazol, 1,3-imidazol, aza-pirimidin, fluoro-deaza-purin i cijanouričnih supstitiranih derivata L-askorbinske kiseline i derivata 1H-10-oksa-1,4-diaza-dibenzo[a,d]heptalena kao potencijalnih agensa protiv malignih humanih tumora i patogenih virusa; c) purina i pirimidina sa zasićenim, nezasićenim i 1,2,3-triazolnim supstituentima, bicikličkih oksazol-, tieno-, furo-, imidazopirimidina kao potencijalnih citostatskih i antiviralnih agensa, te potencijalnih tragača u praćenju malignih tumora primjenom pozitronske emisijske tomografije (PET); d) konjugiranih aromatskih heterocikla, njihovih fotokemijskih i fotofizikalnih karakteristika, reakcijskih mehanizama elektrociklizacije i intra/intermolekularnih cikloadicija, sinteza heteropolicikla kao sintona za bioaktivne spojeve, porfirinskih liganada za fotokatalizu i fotorazgradnja antibiotika. Osim standardnih metoda organske sinteze, naša istraživačka grupa posjeduje i odgovarajuću stručnost u modernim tehnikama kao što su „click chemistry-based“ pristup, paladijem katalizirane reakcije, fotokemijske reakcije, fotofizikalne studije, organska sinteza potpomognuta mikrovalovima, retrosintetski pristup u sintezi ciljnih molekula i strukturna karakterizacija primjenom 1H-, 13C-, 19F-NMR, 2D NMR, IR, UV, CD, fluorescentnom i masenom spektroskopijom.

Last update: 31.10.2014. 11:56:51

Kontaktirajte nas