CIRTT - Centar za istraživanje, razvoj i transfer tehnologije Sveučilišta u Zagrebu | Centar za istraživanje, razvoj i transfer tehnologije

Faculty of Science, Division of Chemistry, Department of General and Inorganic Chemistry

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Main research field

general chemistry, inorganic chemistry, structural chemistry, bioinorganic chemistry

Specific research areas

structural chemistry, crystallography, inorganic chemistry, chemistry of complexes, bioinorganic chemistry, solid state chemistry, catalysts, materials

Techniques/methods

Classical chemical synthesis, grinding, solvothermal, electroanalytical, microwave and ultrasound methods of synthesis. Thermoanalytical methods (TG, DTA, DSC), IR, UV-Vis spectrometry, NMR, X-ray structural analysis on single-crystal and polycrystalline samples, magnetic measurements.

Equipment

UV-Vis and IR spectrophotometer, TG, DSC, X-ray single-crystal diffractometer, X-ray powder diffractometer

Technology keywords

  • Organic Substances
  • Inorganic Chemistry
  • Ecology
  • Inorganic Substances

Services offered

  • Material characterisation (testings, measurements, various quantitative and / or qualitative analyses)

Market sectors

  • Electronic & Electrical Equipment
  • Software & Computer Services
  • Technology Hardware & Equipment
  • Health Care Equipment & Services
  • Pharmaceuticals & Biotechnology
  • Specialty Chemicals
  • Commodity Chemicals

Short summary (English)

One of the research fields is based on synthesis, characterization and elucidation of particular reaction mechanisms of new materials and biologicaly active compounds (eg. hidroxypyrone, amino acids, pyrodoxal, thiosemicarbazones derivatives and their vanadium, chromium, molybdenum and tungsten complexes). To understand the connection between the structure and the physical and chemical properties, the characterization of intermolecular and intramolecular interactions is fundamental for developing synthesis metodology and structural design of new materials with desirable properties. Another field of researh are cadmium and mercury complexes/adducts and cocrystals based on molecular recognition with nucleic acids components. The control of competition of halogens with pyridinemonocarboxylic and pyridinedicarboxylic acids includes also its derivates. Complexation of these polydentate ligands with metals (vanadium, chromium, cobalt, nickel and copper) that are essential for living organisms is also investigated. The crystal and molecular structures of many different biological macromolecules (insulin, tyrosine phenol-lyase, hydroksianthranilate 3,4-dioxygenase etc.) are determined. The X-ray structural study of biological macromolecules is an important step in determination of their functions and for understanding the mechanism. Crystal structures of small molecules that can be models for the active centers of biological macromolecules are determined. The investigation of non-covalent interactions of molecular solids performs with the purpose of defining of their influence to the physical and chemical properties. Different sorts of Schiff bases, other polidentate ligands and their metal complexes are designed and synthesized by ball-mill grinding. The techniques of thermal, spectroscopic and X-ray structure analysis are used in determination of their intrinsic properties.

Short summary (Croatian)

Jedno područje istraživanja obuhvaća sintezu i karakterizaciju novih materijala i biološki aktivnih spojeva (hidroksipirona, aminokiselina, piridoksala, tiosemikarbazona i njihovih kompleksnih spojeva s vanadijem, kromom, molibdenom i volframom) te objašnjenje mehanizama reakcija. Povezivanje strukturnih karakteristika novih spojeva s njihovim fizičkim i kemijskim svojstvima trebalo bi pridonijeti pojašnjenju odnosa struktura-svojstva. Tu posebnu ulogu imaju međumolekulske interakcije i njihova karakterizacija, budući da predstavljaju osnovu razvoja metodologije u sintezi i dizajnu struktura novih materijala posebnih svojstava. Drugo područje obuhvaća istraživanja kadmijevih i živinih kompleksa/adukta te spojeva koji su nastali kokristalizacijom preko molekulskog prepoznavanja s komponentama nukleinskih kiselina. Kontrola kompeticije halogena i piridinmonokarboksilnih i piridindikarboksilnih kiselina uključuje i njihove derivate. Kompleksiranje spomenutih polidentatnih liganada proširuje se i na metale od esencijalnog značaja za žive organizme kao što su vanadij, krom, kobalt, nikal, bakar. Jedna grupa istražuje kristalne i molekulske strukture različitih bioloških makromolekula (inzulin, tirozin fenol-liaza, 3-hidroksiantranilat-3,4-dioksigenaza i dr.) metodom rentgenske strukturne analize što vrlo je važan korak za određivanje njihovih funkcija i razumijevanje mehanizama reakcija. Određuju se i kristalne strukture malih molekula koji mogu poslužiti kao modelni spojevi za biološke makromolekule. Izvode se sveobuhvatna istraživanja u području kemije molekulskih krutina kao doprinos istraživanju nekovalentnih interakcija (dipol-dipol interakcije, vodikove veze, halogenske veze) i njihov utjecaj na fizikalna i kemijska svojstva tvari. Istraživanja su usmjerena na dizajn i pripravu spojeva iz modelnih skupina Schiffovih baza, drugih kelatnih liganada i njihovih koordinacijskih spojeva uz korištenje tehnika rentgenske strukturne i termičke analize te spektroskopije uz primjenu mehanokemijske sinteze u čvrstom stanju.

Last update: 11.02.2013. 05:52:24

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